The cause of Alzheimer's may come from your mouth

In recent years, an increasing number of scientific studies have led to a shocking scientific conclusion: Alzheimer's disease may not just be a disease of the brains of the elderly, but a product of an infection.

In recent years, a growing body of scientific research has supported a troubling hypothesis: Alzheimer's disease may not simply be a condition of brain aging, but rather the product of an infection.

Although researchers are still trying to isolate the exact mechanism of this infection, several studies suggest that the lethal emergence of Alzheimer's disease goes further than we thought.

One such study, published in 2019, is one of the clearest leads yet to blame bacteria for Alzheimer's disease, and it comes from a somewhat unexpected quarter.

Related: Microbes in your mouth may affect your risk of cognitive decline

Watch the video below for a summary of their study:

In a paper led by lead author Jan Petempa, a researcher at the University of Louisville, following the death of a patient with porphyromonas (the researcher behind porphyromonis patients (also known as pathogens in Alazheimer's patient disinfection).

It wasn't the first time the two factors were linked, but researchers went further.

In separate experiments in mice, oral infection with the pathogen led to brain colonization by the bacteria along with increased production of amyloid beta (Aβ), a sticky protein commonly associated with Alzheimer's disease.

Related: This popular diet appears to reduce gum, scientists say

The research team, coordinated by pharmaceutical startup Cortexyme, which was co-founded by first author Stephen Dominy, did not claim to have found definitive evidence of the cause of Alzheimer's.

But it's clear he thought we had a strong case here.

"Infectious agents have previously been implicated in the development and progression of Alzheimer's disease, but the evidence for causation is not conclusive," Duminy said at the time.

"Now, for the first time, we have solid material linking the riverine, Gram-negative pathogen, P. ginguisis, and Alzheimer's pathogenesis."

Additionally, the team calls the Alzheimer's brain the brain, the disease brain the brain, and the crop brain.

Related: Stomach ulcer bacteria may be a surprising ally against Alzheimer's disease

But even more, the team identified the toxic game in the brains of people who died and could not be diagnosed Alzhimer.

This is important because, although P. gingivalis and the disease have been linked before, it has never been known, simply put, whether gum disease causes Alzheimer's disease or whether dementia is caused by poor oral hygiene.

They were also the sins of the ignoble lower castes, and they had a long history of their condition.

"Our identification of gingipain antigens in the brains of people with AD, as well as those with AD pathology but without a diagnosis of dementia, shows that P. gingivalis brain infection is not the result of poor dental care after the onset of dementia or the result of late-stage disease," the authors explained in their paper.

"But it is an early event that may explain the pathology that occurs in middle-aged individuals before cognitive decline."

And the company, also called CORV388, has shown experiments in mice that can reduce the brain damage of Amyloid-beta.

We'll have to wait and see what research comes out of this relationship, but the research community is very active.

RELATED: Now we may know why Alzheimer's erases the memories of our loved ones

Today, Alzheimer's disease is the most common form of dementia and the leading cause of death in the United States.However, despite numerous studies, no one knows how the disease starts or how to stop its progression.

Major risk factors for disease in the US appear to have changed over the past decade.

In 2011, the best-known, modifiable risk factor for Alzheimer's disease was physical inactivity, followed by depression and smoking.

According to the 2022 group that works for free, however, practicing this exercise is at an ineffective stage in impurity when it comes to development.

"It is important that we test as many approaches as possible to fight diseases like Alzheimer's," David Reynolds, chief scientific officer of Alzheimer's Research, said in a statement.

The research was reported in Science Advances

An earlier version of this story was published in January 2019.