Aug 21, 2025
3 min read
Find out how 'noise' Chromatin affects cellular identification and immune training, and the effects of direct vaccine and cancer development.
"Indicate"
A new research suggests that the DNA is packaged can enable cells to identify another cell types.
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All cells in the body have the same DNA, but different types of cells express different genes;Skin cells express skin genes, liver cells express liver genes, etc.This coordination is important to help cells distinguish their prescribed roles, but a new study by university researchers shows how to express the genes reserved for other types of cells in general to "close" genome areas.
During this week, the DNA can create a kind of epistolic sound "pack".The immitio has a significant role in the tissue and the immune system of the immune system, but also develops the tumors.
"We believe that this skill changes a manual that does not feel comfortable and we want to investigate methods."
Opening, noisy and vibrate
Koh recently recently of Noah Gomble, head of the book, working in the cell cell cells (MTEC).Do
MCSCPhytors used in use used in use in use
The ability to disclose almost any gene and edit their identity has made the MTEC a great candidate to study their fate."There is only one diverse."There is a great deal, so we thought it was really important to look like a cell to detect the mechanism that enabled each sub -group of specific tissue genes.“
Since such heterogeneity is important, Gamble used a number of single cell sequence techniques to examine gene expression and the chromatin structure in individual MTECs instead of using conventional bulk sequencing tools that have on average the results of thousands of cells on average.
Chromatine is a DNA and protein complex in the core that packs long DNA areas in compact structures.When chromatine is freptier packaged or open, genes are more willing to activate than if it is a densely spot.
When the data analyzes, it was unable to find contacts between the level of the chromatin real genes and the real tissue level, which in turn helped activate the genes indicated in other specialized tissues.This "ectopic expression", in turn, helped them teach themselves and self-division.
"Qromatin usually condemns to break the regions of the nutrition and access to the relevant regions," the gambling."On our background, we will find that its genomic areas should be good to access different types of genes for different types of genes for different types of genes.
Ngindhari 'genome genome'
The team then tried to understand how this "chromatin noise" increases in the cells.They discovered that the activity of the protein depressing tumor P53, called the "Genomanian guard", suppresses the MTAC before their genomics become too relaxed.So there were smart games and Koh that he would be involved in the process of epithelial cells dedicated to tissues and other organs.
Researchers P53 operations will be improved in MTECs, chromatins were more stable, epigenetic noise was rejected, and the cells could not activate specific tissue genes.In the last analysis, this has led to the disease of many organs with the Timus's Timus Timal T-Cell.
"This shows that the Epita-Extets of Epita-Exta negative states will develop the death of a P53 and a person.""But because this is the instailpic display is not paid for yourself / freedom."
This is an idea that attracts to think that cells are programmed to get rid of ginger to give them more combinations to prevent problems for more strategies.Easy to hope to investigate another cancer type using the same page ador.
The team also wants to see if epigenetic noise will amplify for wound healing and tissue repair, and if it can be used to reprogram it to alternate phenotypes in a variety of clinical environments, including cancer immunotherapy and autoimmunity treatment.
"It covers the logo meaning of the logo. Also about a random process to identify any entity in the universe."The moral aspects of the story is sometimes sometimes as important as random words signals.".
Reference: Gambling n, Cald Wheel G, Mikkel Je, and more.The Timc Epithelian cells creates an edigitic sound to improve the immune tolerance .2025.Dope: 10.1038 / S41586-025-09424-X-x-x
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