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Researchers of UC San Francisco have identified a single protein that can play a key role in age loss of age.Protein called Ferrithinlys

UC San Francisco scientists have identified a single protein that can play a major role in age -related memory.

Protain, called on a light chain (Ftr1), Accumulates in a hugged area of which gets older and is associated with a worse mice and is sometimes related to worse muse.Using damage.Found, published in nature becoming older, showing a promising aim to handle a mental decline.

Why is one of the single protein on the hippamasmps old

The hippocampus, the center for training and memory, is one of the nucleists increasingly negative for standard memory work in the mouse.

How to reactivate the reasons and experiences

To move beyond the adapter, the team has directly handled FTL1:

- Overexpression in young mice: The enlargement of neuronal FTL1 reduced the complexity of dendritis, depressed the potential for a long time, and eliminated preference for novels and maze hand items.

- Skanding and knockout CRISPR in old mice: FTL1 Neuron reduction increased synaptic markers and resumed memory performance at the youth level.

- Metabolis's metabolis: OMCS-OMCS required by ATP Syarthies.First TTN

- Nodh Redcue: Nadhada Increasing, Nadid, which lightened losses and losses of loss and rescue memories of FTL1-owsrexpres to get rodents.

Saul said, "This is to break really weaknesses."It is a good time to work on the old biology."

Brain Targate's FTL1 agitation indicates translation paths

FTL1 is at the intersection of iron biology and neuronal metabolism, iron deregulation can damage mitochondria, damage ATP production and cause oxidative stress.The authors' two -way attempts support FTL1, as not only a passenger, with the aging of the hippocampus.It corresponds to wider evidence as the highest level of ferritin mimics cognitive problems in larger adults, this approach makes FTL1 an attractive purpose for interventions that adapt to iron handling or strengthen cell energy, which can potentially be studied with other strategies.

What do you see next?

Before any human application, scientists will need to try the security and length of the FTL 1 module of modulation, and the map effects in the brain will be expanded, Alzheimer's, Parkinson's, Parkinson's and Parkinson's, Parkinson's, Parkinson's, Parkinson's, ParkinsonIron homesasasis.Future studies are repeated in old animals and diseases, can be FTL 1 for a cognitive defense of old age.

Nature Aging magazine, UCSF Institute, the National Institute for Aging, Information on the UCSF Institute, Nursing and Brain Health and Alzheimer Association.

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